Chronic inflammation and abdominal obesity can together cause and worsen several diseases. Metabolically active abdominal fat, especially visceral fat, can create inflammatory chemicals, causing chronic low-grade inflammation.
Adipose tissue, especially visceral fat, releases pro-inflammatory compounds such cytokines (e.g., interleukin-6, tumor necrosis factor-alpha) and adipokines (e.g., leptin). These chemicals can cause and maintain systemic inflammation.
Linking Insulin Resistance to Abdominal Fat: Cells become insulin-resistant when belly fat increases. Insulin resistance causes metabolic dysfunction and inflammation.
Metabolic Syndrome Parts: Chronic inflammation is central to metabolic syndrome, which includes abdominal obesity, insulin resistance, elevated blood pressure, and abnormal cholesterol levels.
Cardiovascular Diseases: Atherosclerosis: Chronic inflammation contributes to plaque formation in artery walls. Hypertension and dyslipidemia are linked to abdominal fat.
Type 2 Diabetes: Insulin Dysfunction Type 2 diabetes can result from abdominal fat-induced inflammation that disrupts insulin signaling. People with abdominal obesity often have insulin resistance and glucose metabolism issues.
Cancer: Inflammatory Microenvironment: Chronic inflammation can increase cancer start and progression. Obesity and inflammation raise the risk of colorectal, breast, and pancreatic cancers.
A balanced diet, regular exercise, and weight management reduce belly fat and chronic inflammation, minimizing the risk of related disorders.
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